Src Family Kinases in Epidermal Homeostasis, Wound Healing, and Tumorigenesis

Stratified squamous keratinocyte cells make up the epidermis, the skin's outermost layer, and most cells in the inner layer at the base of the epidermis are progenitor or stem cells. The outer layer of the epidermis is formed through the continuous migration, differentiation, and proliferation of its cells. On the surface of the epidermis, stem cells or progenitor cells replace the dead cells through a balance of proliferation and differentiation. Pathological changes like carcinogenesis can result from genetic changes in signaling networks that control migration, differentiation, and proliferation. These changes also affect the wound healing process. This study examines the current functions of Src family kinases, which regulate cancer formation, wound healing, and epidermal maintenance. Treatment for cancer and uncontrolled wound recuperation may benefit from an understanding of the pathways controlled by the Src family kinase. Published by 4-Green Research Society .

Keywords: Epidermis, keratinocyte, proliferation and differentiation, Src family kinase, wound recuperation..